While the action of cranberry proanthocyanidins against the adhesion of Escherichia coli bacterium on urinary tract cells has been reported previously, the company has reported that its cranberry extract CranPure, standardized to 30 per cent proanthocyanidins, may inhibit the adhesion between E.coli and urinary tract cells T24 up to 75 per cent.
Preliminary data indicated greater efficacy against E. coli strains with p-fimbriae, claimed to be the most pathogenic. The company confirmed that further studies are ongoing.
While the link between cranberries and UTI’s is well known amongst consumers, particularly women, the European Food Safety Authority (EFSA) appears not overly convinced. Unrelated to Diana's cranberry ingredient, EFSA last week when it issued a negative opinion to global cranberry leader Ocean Spray for an article 14 health claim relating consumption of cranberry and urinary tract infection (UTI) in women.
EFSA’s Panel on Dietetic Products, Nutrition and Allergies (NDA) found Ocean Spray’s scientific dossier failed to support a link between UTI reduction and consuming Ocean Spray cranberry products containing 80mg of cranberry proanthocyanidins (PAC) per serving.